Table 1 Cul5-containing ubiquitin ligases and the corresponding substrates

SOCS1

JAK2

[63]

Vav

[61]

IRS1 and IRS2

[66]

GM-CSF receptor βc subunit

[60]

Cdh1

[65]

p65

[67]

Mal

[64]

HPV E7

[62]

SOCS6

Cas

[69]

SOCS7

Dab1

[86]

SPSB1, 2, and 4

iNOS

[93, 94, 98, 99]

SPSB1

TGF-β type II receptor

[102]

ASB2

Filamin A and B

[107–110]

Jak3

[112, 113]

ASB3

TNF-R2

[115]

ASB4

IRS4

[118]

ID2

[124]

ASB6

APS

[125]

ASB9

CKB

[130, 131]

uMtCK

[132]

ASB11

DeltaA (in Danio rerio)

[139, 140]

Ribophorin 1

[104]

WSB1

HIPK2

[144]

D2

[160]

pVHL

[165]

RhoGDI2

[166]

Rab40

Rap2 GTPase

[167]

Elongin A

Rpb1

[170]

Vif (human immunodeficiency virus)

APOBEC3F

[188]

APOBEC3G

[186]

BZLF1 (Epstein–Barr virus)

p53

[224, 225]

E1B55K (adenovirus)

p53

[235, 236, 239]

Mre11

[227]

DNA ligase IV

[241, 242]

integrin α3

[243]

Rep52 and capsid proteins

[244, 245]

LANA (Kaposi’s sarcoma–associated herpesvirus)

pVHL and p53

[254]