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Fig. 5 | Cell Division

Fig. 5

From: The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor

Fig. 5

TBX3 promotes chondrosarcoma cell proliferation in a dose dependent manner which correlates inversely with p21 protein and mRNA levels. a SW1353 shTBX3 cells were transiently transfected with either 50 ng or 300 ng pCMV-TBX3 and growth curve assays were performed over a 3 day period. b Western blotting and c qRT-PCR show a correlation between cell proliferation and the expression of transfected TBX3 and p21 protein and mRNA levels in SW1353 shTBX3 cells. Error bars indicate standard deviation (*p < 0.05 and ***p < 0.001)

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