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Fig. 6 | Cell Division

Fig. 6

From: The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor

Fig. 6

The repression of p21 is required for TBX3 induced cell proliferation. a SW1353 cells were transiently transfected with either 25 nM sip21 or siControl for 12 h. Growth curve assays were performed over a 3 day period (upper panel sip21#1, lower panel sip21#2.). b SW1353 cells were transiently transfected with either pRc/CMV-Empty (control) or pRc/CMV-p21 (p21). Growth curve assays were performed over a 3 day period (right panels). (a, b) Two way ANOVA test was performed to calculate statistical significance (***p < 0.001). Left panels western blotting to confirm the expression of the indicated proteins using antibodies to TBX3, p21 and p38 (loading control)

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