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Fig. 5 | Cell Division

Fig. 5

From: Insights into APC/C: from cellular function to diseases and therapeutics

Fig. 5

APC/C in genomic integrity, apoptosis, autophagy, senescence, metabolism, stem cell and neuron regulation. The up panel shows APC/C controls several process including genomic integrity, apoptosis, autophagy, senescence, metabolism, stem cell and neuron regulation. In genomic integrity regulation part, genotoxic stress induced APC/C–Cdh1 activation and subsequently ubiquitylates substrates Rad17, Claspin and USP1 to regulate cell cycle checkpoint and recovery. In senescence process, APC/C–Cdh1 is activated by CDC14B and p21 to ubiquitylate substrates G9a and GLP and subsequently provokes IL-6 and IL-8 transcription. In apoptosis panel, Cdh1 targets MOAP1/Bax and Cdc20 targets Mcl1 and Bim1 to control apoptosis process. In metabolism regulation, APC/C–Cdh1 targets PFKFB3 and GLS1 to control glycolysis and glutaminolysis. In neuron, APC/C–Cdh1-mediates degradation of fragile X syndrome protein (FMRP), CK1δ, GluR1, Liprin-α, and Pfkfb3, APC/C–Cdc20 mediates ubiquitylation of Id2 and SnoN. In Stem cell, APC/C–Cdc20 mediates degradation of p21 and regulates pluripotency-related transcription factor SOX2 protein transcription activity. The down panel shows how APC/C potential controls autophagy process. APC/C–Cdh1-mediates degradation of PFKFB3, a critical factor in glucose metabolism and induces autophagy. Loss of PTEN, reduces APC/C–Cdh1-mediated degradation of PFKFB3, lead to strong inhibition of autophagy. On the other hand, APC/C–Cdh1 mediated chromatin accumulated PTEN degradation during mitotic exit

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