Fig. 4

A schematic summary of CRLs substrates in the regulation of autophagy. CRLs control autophagy at multiple levels. First, CRLs mediate the ubiquitination of several components of autophagy machinery. Second, CRLs regulate the activation of mTOR pathway, the central regulator of autophagy. At last, several key transcription factors involved in autophagy are also the substrates of CRLs. See text for details