Model for Rpl22 function. a Location of Rpl22 (red), Rpl29 (green), Rpl39 (yellow), central protuberance (CP) and peptide exit channel (PEC) are indicated. b Cartoon of IME1 gene structure with upstream promoter elements repressed by dextrose or nitrogen. Ribosome stalling on the 5′UTR is indicated resulting in low Ime1 production. Release of Rpl22 activity from nitrogen repression allows full IME1 mRNA translation and increased Ime1 production sufficient for meiotic progression.