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Fig. 1 | Cell Division

Fig. 1

From: The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

Fig. 1

General view of the NSP: once a ligand of the DSL family in the signal sending cell interacts with the Notch receptor of the signal receiving cell, NICD is released by proteolysis and translocated to the nucleus activating the pathway for a positive gene regulation together with CSL proteins, Mastermind (Mam) protein and histone acetyltransferases (HATs). Otherwise NSP is repressed by “default repression” complexes structured by Hairless (H) protein and C-terminal binding protein (CtBP) and Groucho (Gro) co-repressors

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