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Fig. 3 | Cell Division

Fig. 3

From: The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

Fig. 3

Comparative view of the repression and activation complexes. One of the best known models of the NSP is Drosophila melanogaster. CSL transcription factor acts as a bridging protein between the DNA and a complex of proteins intended to modify chromatin topology in a specific locus. In the case of the gene repression complex, CSL recruits H that in turn will form a HDAC together with Gro and CtBP. Even if H is the main co-repressor of the pathway in the fly fruit, no H homolog has been found in models out of insects, but instead a series of other proteins seem to take this function as we will see further. For the gene activation complex, NICD and Mam occupied the CSL’s domains and, in turns, recruit a HAT complex to generate an open chromatin topology and promote gene expression. Activation complexes seem to be similar in all models where NSP has been studied. Skip is common in both complexes

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