Phasing in on the cell cycle

Cell Division

Table 2 Phase separated proteins whose function affects the cell cycle

Protein name	Effect on cell cycle	Phase separation
Nucleolus
FIBL	Knockdown reduces cell growth [57]	[12]
NPM-1^a	Role in tumorigenesis [58]	[12]
Stress granule
eIF4G2	Knockdown induces apoptosis and impairs proliferation [59]	[9]
FUS^a	Knockdown impairs cell proliferation [60]	[6, 8, 9, 51]
EWS^a	Knockdown induces apoptosis and impairs proliferation [61]	[2]
hnRNPA1	Knockdown induces cell cycle arrest [62]	[7, 9]
TDP-43	Overexpression induces cell cycle arrest [63]	[64]
TIA-1	Knockdown promotes cell proliferation [65]	[9]
Centrosome
PCM-1	Involved in cell cycle progression [66]	[67]
Purinosome
PPAT	Regulates growth rate via de novo purine biosynthesis [68]	[69]
Nuclear pore
Nup98^a	Regulates expression cell cycle genes [70]	[71]
T-cell receptor
LAT	Regulates T-cell activation and proliferation [72]	[40]

ISSN: 1747-1028