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Table 2 Phase separated proteins whose function affects the cell cycle

From: Phasing in on the cell cycle

Protein name

Effect on cell cycle

Phase separation

Nucleolus

 FIBL

Knockdown reduces cell growth [57]

[12]

 NPM-1a

Role in tumorigenesis [58]

[12]

Stress granule

 eIF4G2

Knockdown induces apoptosis and impairs proliferation [59]

[9]

 FUSa

Knockdown impairs cell proliferation [60]

[6, 8, 9, 51]

 EWSa

Knockdown induces apoptosis and impairs proliferation [61]

[2]

 hnRNPA1

Knockdown induces cell cycle arrest [62]

[7, 9]

 TDP-43

Overexpression induces cell cycle arrest [63]

[64]

 TIA-1

Knockdown promotes cell proliferation [65]

[9]

Centrosome

 PCM-1

Involved in cell cycle progression [66]

[67]

Purinosome

 PPAT

Regulates growth rate via de novo purine biosynthesis [68]

[69]

Nuclear pore

 Nup98a

Regulates expression cell cycle genes [70]

[71]

T-cell receptor

 LAT

Regulates T-cell activation and proliferation [72]

[40]

  1. a Highlights protein found as oncogenic fusion proteins [46,47,48,49, 52]