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Table 2 Phase separated proteins whose function affects the cell cycle

From: Phasing in on the cell cycle

Protein name Effect on cell cycle Phase separation
Nucleolus
 FIBL Knockdown reduces cell growth [57] [12]
 NPM-1a Role in tumorigenesis [58] [12]
Stress granule
 eIF4G2 Knockdown induces apoptosis and impairs proliferation [59] [9]
 FUSa Knockdown impairs cell proliferation [60] [6, 8, 9, 51]
 EWSa Knockdown induces apoptosis and impairs proliferation [61] [2]
 hnRNPA1 Knockdown induces cell cycle arrest [62] [7, 9]
 TDP-43 Overexpression induces cell cycle arrest [63] [64]
 TIA-1 Knockdown promotes cell proliferation [65] [9]
Centrosome
 PCM-1 Involved in cell cycle progression [66] [67]
Purinosome
 PPAT Regulates growth rate via de novo purine biosynthesis [68] [69]
Nuclear pore
 Nup98a Regulates expression cell cycle genes [70] [71]
T-cell receptor
 LAT Regulates T-cell activation and proliferation [72] [40]
  1. a Highlights protein found as oncogenic fusion proteins [46,47,48,49, 52]