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Table 3 Indirect mediators of the cell cycle known to be substrates and interacting partners of PRMTs

From: Protein arginine methylation: an emerging regulator of the cell cycle

Protein

Interacting PRMT

Known methylated residues

Result of methylation or PRMT interaction

Refs.

Androgen receptor

PRMT2

–

Co-activator allowing translocation into the nucleus

[152]

PRMT5

–

Activator of the AR

[154]

PRMT10

–

Knockdown of PRMT10 suppressed cell growth in LNCaP cells

[153]

CREB-binding protein

PRMT4

R600

Disrupts CREB binding

[155]

R742

Regulates transcriptional activation of steroid hormone receptors

[156]

Estrogen receptor α

PRMT1

R260

Cytoplasmic localisation of ERα prevents phosphorylation of PKB/AKT

[148]

PRMT2

–

Co-activator of ERα, implicated in tumour cell growth

[149]

INCENP

PRMT1

R887

Enhances binding with inner centromere protein (INCENP) to regulate chromosomal alignment and segregation

[147]

MDM4

PRMT5

–

Alternate splicing of MDM4 activates p53 in response to PRMT5 depletion

[172]

p300

PRMT4

R580

Methylation of p300 activates p21 to inhibit cell cycle progression

[155]

R754

PRMT4 complexes with p300, BRCA1 and p53 to induce expression of p21

[157]

Sam68

PRMT1

R45, R52, R304, R310, R315, R320, R325

Methylation of Sam68 regulates its localization and reduces its RNA-binding ability

[169]

[170]

PRMT2

–

Regulates alternative splicing of Bcl-x

[168]

SF2/ASF

Unknown

R93, R97, R109

Regulates subcellular localization and activity of SF2/ASF

[171]

Telomere repeat binding factor 2

PRMT1

R17, R18

Regulates telomere length and stability

[146]

Ubiquitin-associated protein 2-like

PRMT1

N-terminus region

Regulation of chromosome alignment during mitosis

[44]