From: Protein arginine methylation: an emerging regulator of the cell cycle
Protein | Interacting PRMT | Known methylated residues | Result of methylation or PRMT interaction | Refs. |
---|---|---|---|---|
Androgen receptor | PRMT2 | – | Co-activator allowing translocation into the nucleus | [152] |
PRMT5 | – | Activator of the AR | [154] | |
PRMT10 | – | Knockdown of PRMT10 suppressed cell growth in LNCaP cells | [153] | |
CREB-binding protein | PRMT4 | R600 | Disrupts CREB binding | [155] |
R742 | Regulates transcriptional activation of steroid hormone receptors | [156] | ||
Estrogen receptor α | PRMT1 | R260 | Cytoplasmic localisation of ERα prevents phosphorylation of PKB/AKT | [148] |
PRMT2 | – | Co-activator of ERα, implicated in tumour cell growth | [149] | |
INCENP | PRMT1 | R887 | Enhances binding with inner centromere protein (INCENP) to regulate chromosomal alignment and segregation | [147] |
MDM4 | PRMT5 | – | Alternate splicing of MDM4 activates p53 in response to PRMT5 depletion | [172] |
p300 | PRMT4 | R580 | Methylation of p300 activates p21 to inhibit cell cycle progression | [155] |
R754 | PRMT4 complexes with p300, BRCA1 and p53 to induce expression of p21 | [157] | ||
Sam68 | PRMT1 | R45, R52, R304, R310, R315, R320, R325 | Methylation of Sam68 regulates its localization and reduces its RNA-binding ability | [169] [170] |
PRMT2 | – | Regulates alternative splicing of Bcl-x | [168] | |
SF2/ASF | Unknown | R93, R97, R109 | Regulates subcellular localization and activity of SF2/ASF | [171] |
Telomere repeat binding factor 2 | PRMT1 | R17, R18 | Regulates telomere length and stability | [146] |
Ubiquitin-associated protein 2-like | PRMT1 | N-terminus region | Regulation of chromosome alignment during mitosis | [44] |