TY - JOUR AU - Keppeke, Gerson Dierley AU - Chang, Chia Chun AU - Peng, Min AU - Chen, Li-Yu AU - Lin, Wei-Cheng AU - Pai, Li-Mei AU - Andrade, Luis Eduardo Coelho AU - Sung, Li-Ying AU - Liu, Ji-Long PY - 2018 DA - 2018/06/15 TI - IMP/GTP balance modulates cytoophidium assembly and IMPDH activity JO - Cell Division SP - 5 VL - 13 IS - 1 AB - Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregate into a macrostructure, termed the cytoophidium, in mammalian cells under a variety of conditions. However, the regulation and function of the cytoophidium are still elusive. SN - 1747-1028 UR - https://doi.org/10.1186/s13008-018-0038-0 DO - 10.1186/s13008-018-0038-0 ID - Keppeke2018 ER -