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Table 1 Structure and role of the catalytic subdomains of Aurora kinases

From: The functional diversity of Aurora kinases: a comprehensive review

Kinase domain lobe Kinase subdomain Structure Role
N-terminal I Glycin-rich loop ATP-binding
II Invariant lysine
III   
IV   Structure of the N-terminal lobe
C-terminal V   
VIB   Mg2+ chelator
VII In front to the catalytic cleft  
VIII   Substrate binding
IX   Structure and active conformation of the kinase
X   Substrate binding
XI   Substrate binding
XII