Table 1 Structure and role of the catalytic subdomains of Aurora kinases

N-terminal

I

Glycin-rich loop

ATP-binding

II

Invariant lysine

III

IV

Structure of the N-terminal lobe

C-terminal

V

VIB

Mg²⁺ chelator

VII

In front to the catalytic cleft

VIII

Substrate binding

IX

Structure and active conformation of the kinase

X

Substrate binding

XI

Substrate binding

XII