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Fig. 5 | Cell Division

Fig. 5

From: Reactivation of TAp73 tumor suppressor by protoporphyrin IX, a metabolite of aminolevulinic acid, induces apoptosis in TP53-deficient cancer cells

Fig. 5

Protoporphyrin IX inhibits the growth of HCT 116 p53−/− xenograft tumors. a Inhibition of tumor growth after intravenous injections of PpIXNa (7.5 mg/kg/day) for day 1, 3, 6, 10 and 13. The results are shown as mean of SD (n = 5 for each group). b TAp73 is upregulated in PpIXNa-treated tumors with concomitant induction of PARP-1 cleavage

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