Fig. 1

Structural organization of the APC/C. a, b EM construction of the APC/C^CDH1 in complex with the inhibitory protein Emi1. Reproduced with permission from [9]. c Schematic of the Apo-APC/C. d active APC/C. Positions of IR tail binding sites and C-box binding sites are shown. Change in the mobility of the platform and repositioning of the catalytic core upon substrate binding is indicated. e Domain organization and modification sites of CDC20 (upper) and CDH1 (lower) with known CDK1 phosphorylation sites (dark green)