Fig. 3

Post-translational modifications and the order of substrate degradation. Temporal pattern of APC/C activity in context with CDC20 (in blue) and with CDH1 (in red) in different cell cycle phases is shown on the left. Substrates are shown on top in the order of their degradation. The blue box denotes the CDC20-mediated, and orange box shows the CDH1 mediated degradation of the substrates. The substrates undergo various post-translational modifications that also contribute to the order in which they are degraded. These PTMs are color coded, with darker to lighter shading, where darker shade represents higher amount of protein and vice versa