Motif | Consesus sequence | Coactivator | Substrate | Function | References |
---|---|---|---|---|---|
D-box | RxaxLx[D/E][Ø]xN[N/S] | CDC20, CDH1 | Securin, Cyclins | Proteolytic degradation | [70] |
KEN-box | KENxxxN | CDH1 | CDC20, NEK2A | Proteolytic degradation | [145] |
ABBAmotif | Fx[ILV]c[FHY]x[DE] | CDC20 | Cyclin A, BUBR1, BUB1 and ACM1 | Proteolytic degradation | [71] |
A-box | QRILGPS*bNVPQRV | CDH1 | Aurora A kinase | Regulatory domain for proteolytic degradation | [35] |
O-box | AS[P]LT[E][K][N][A]K | CDH1 | ORC1 | Proteolytic degradation | [73] |
CRY-box | CRYxPS | CDH1 | CDC20 | Proteolytic degradation | [72] |
GxEN | GxEN | CDC20, CDH1 | XKID (Xenopus chromokinesin Kid) | Proteolytic degradation | [74] |
SPO13 | QK[P]LQ[E][K][T][P]N | CDH1 | SPO13 | Proteolytic degradation | [146] |
CIN8P | KM[P]LR[L][S][N][I]N | CDH1 | CIN8P | Proteolytic degradation | [147] |
TEK-box | R/KxxTxKT | CDH1 | Securin | K-11 ubiquitination | [148] |
C-box | DRYIPHR | CDH1, CDC20 | APC | APC/C association | [64] |