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Table 1 Motifs recognised by CDC20 and CDH1 in known APC/C substrates

From: Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome

MotifConsesus sequenceCoactivatorSubstrateFunctionReferences
D-boxRxaxLx[D/E][Ø]xN[N/S]CDC20, CDH1Securin, CyclinsProteolytic degradation[70]
KEN-boxKENxxxNCDH1CDC20, NEK2AProteolytic degradation[145]
ABBAmotifFx[ILV]c[FHY]x[DE]CDC20Cyclin A, BUBR1, BUB1 and ACM1Proteolytic degradation[71]
A-boxQRILGPS*bNVPQRVCDH1Aurora A kinaseRegulatory domain for proteolytic degradation[35]
O-boxAS[P]LT[E][K][N][A]KCDH1ORC1Proteolytic degradation[73]
CRY-boxCRYxPSCDH1CDC20Proteolytic degradation[72]
GxENGxENCDC20, CDH1XKID (Xenopus chromokinesin Kid)Proteolytic degradation[74]
SPO13QK[P]LQ[E][K][T][P]NCDH1SPO13Proteolytic degradation[146]
CIN8PKM[P]LR[L][S][N][I]NCDH1CIN8PProteolytic degradation[147]
TEK-boxR/KxxTxKTCDH1SecurinK-11 ubiquitination[148]
C-boxDRYIPHRCDH1, CDC20APCAPC/C association[64]
  1. ax signifies any amino acid residue
  2. b* indicates one member of a closely related family of amino acids
  3. c[] square brackets indicates any of the bracketed amino acid