Fig. 2

Increased essentiality among checkpoints and S phase genes in both cell types, decreased growth-restriction in cancer. a Fractions of essential genes in different gene sets in ESCs (hESCs; red bars) and cancer cells (grey bars). b Fractions of growth-restricting genes in different gene sets in ESCs (red bars) and cancer cells (grey bars). c Percentages of essential and growth-restricting genes among genes related to different cell cycle phases in ESCs (left) and cancer cells (right). d CRISPR score distributions of different gene sets in ESCs (left) and in cancer cells (right). CRISPR score per gene for cancer cells represents the average score across four transformed cell lines