Fig. 4
From: The essentiality landscape of cell cycle related genes in human pluripotent and cancer cells
Differential essentiality and growth-restriction analysis of cell cycle genes in ESCs and cancer cells: a Differentially essential genes ranked according to a differential score calculated by subtracting cancer cell CRISPR score of each gene from its ESC CRISPR score. Genes associated with the spindle-assembly checkpoint are highlighted. b Schematic representation of the spindle-assembly checkpoint pathway. c Differentially growth-restricting genes between ESCs and cancer cells ranked according to the difference between the CRISPR scores obtained in the screens using these cell types. d Protein interactome analysis of growth-restricting checkpoint genes in ESCs