Fig. 5

Toll triggers JNK-dependent cell death in eye development. Light micrographs of Drosophila adult eyes (a–c) and fluorescent micrographs of third instar larval eye discs (e–g) are shown. Compared with the GMR-Gal4 controls (a, e), Toll^10B-induced small eye phenotype (b) and cell death (f) are suppressed by expressing Bsk^DN (c, g). d, h Statistical analysis of the adult eye size/wild type (WT) (n = 10) and cell death number in eye discs (e, n = 10; f, n = 8; g, n = 10) are shown. One-way ANOVA was used to compute P-values, ****P < 0.0001. See Additional file 1 for detailed genotypes. Scale bar: 100 μm