Fig. 6
From: Toll signaling promotes JNK-dependent apoptosis in Drosophila
Toll induces ROS-dependent JNK activation and apoptosis. Third instar larval wing discs showing ROS level (a–d) and puc-LacZ expression (e–h). Compared with the control (a), ectopic expression of Toll10B promotes ROS production (b), which is suppressed by expressing Sod (c), but not BskDN (d). Compared with the control (e), Toll10B-induced JNK pathway activation (f) is suppressed by expressing Sod (g) or BskDN (h). i, j Statistical analysis of the ROS spots (a, n = 10; b, n = 7; c, n = 10; d, n = 9) and X-Gal expression (n = 8) are shown. Kruskal–Wallis test and one-way ANOVA were used to compute P-values, ****P < 0.0001, *P < 0.05 and ns indicates not significant. See Additional file 1 for detailed genotypes. Scale bar: 100 μm