TY - JOUR AU - Mitchell, Ellen AU - Mellor, Charlotte E. L. AU - Purba, Talveen S. PY - 2020 DA - 2020/09/17 TI - XMU-MP-1 induces growth arrest in a model human mini-organ and antagonises cell cycle-dependent paclitaxel cytotoxicity JO - Cell Division SP - 11 VL - 15 IS - 1 AB - XMU-MP-1 is an inhibitor of the Hippo pathway kinases MST1/2 and has been shown to promote the downstream activation of the pro-proliferative, pro-regenerative and anti-apoptotic transcriptional regulator YAP1. We tested whether XMU-MP-1 can activate YAP1 in a model human mini-organ, namely the hair follicle, to determine whether it can be pharmacologically exploited to promote regeneration in the hair follicle as a novel strategy to treat pathological hair loss disorders. SN - 1747-1028 UR - https://doi.org/10.1186/s13008-020-00067-0 DO - 10.1186/s13008-020-00067-0 ID - Mitchell2020 ER -