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Table 5 Thirty-one hub genes with a degree of ≥ 15 in the protein–protein interaction network

From: Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma

Gene ID Fold Change P-value Feature Out Degree In Degree Total Degree Rank
NOTCH1 1.505646 0.000815 Up 13 22 35 1
COL1A1 1.530545 0.047257 Up 20 10 30 2
CYCS − 1.645191 0.007507 Down 7 19 26 3
COL4A1 2.501585 0.002376 Up 19 4 23 4
ACTA2 1.609589 0.029662 Up 21 1 22 5
PDGFRB 1.982871 0.000202 Up 3 18 21 6
KDR 2.478637 0.022919 Up 4 17 21 7
MMP14 1.646649 0.001126 Up 9 12 21 8
ELN 1.559719 0.029079 Up 11 10 21 9
ITGA5 1.859768 0.002024 Up 8 12 20 10
PPP1CC − 1.611769 0.005672 Down 6 13 19 11
UBE2D1 − 2.344914 0.002874 Down 13 6 19 12
PPP1CB − 1.590005 0.005132 Down 16 3 19 13
BGN 1.619226 0.012656 Up 8 10 18 14
COL4A2 2.395693 0.000766 Up 16 2 18 15
DLD − 1.877071 0.001431 Down 0 17 17 16
TLN1 1.548241 0.001011 Up 5 12 17 17
COL6A2 1.539987 0.002659 Up 8 9 17 18
FLNA 1.699094 0.000618 Up 12 5 17 19
ACTN1 1.506622 0.012742 Up 13 4 17 20
ENG 1.567089 0.00081 Up 15 2 17 21
THY1 1.920826 0.007751 Up 6 10 16 22
COL18A1 1.582594 0.000192 Up 11 5 16 23
CUL2 − 1.5414 0.013956 Down 16 0 16 24
NDUFB5 − 1.639639 0.004704 Down 2 13 15 25
MYL9 1.622037 0.02276 Up 3 12 15 26
UBE2B − 1.61738 0.001153 Down 4 11 15 27
LRRK2 − 1.80695 0.001503 Down 7 8 15 28
CUL5 − 1.900919 0.007236 Down 10 5 15 29
ACADM − 1.721258 0.003933 Down 11 4 15 30
ACTG2 1.564071 0.026988 Up 13 2 15 31