Fig. 7From: A positive feedback loop between EZH2 and NOX4 regulates nucleus pulposus cell senescence in age-related intervertebral disc degenerationThe positive feedback loop of EZH2 and NOX4 was involved in NP cell senescence. Changes in EZH2 regulated activation of the upstream promoter of NOX4 through H3K27me3 and H3K27ac. Overexpression of NOX4 inhibited the expression of EZH2 by activating the canonical Wnt/β-catenin pathway, further inducing NP cell senescenceBack to article page