Fig. 5

KRIBB11 enhances anti-mitosis drug-induced spindle defects and cell death in CGL2 cells. a Inhibition of HSF1 with KRIBB11 during mitosis enhanced anti-mitosis drug-induced spindle abnormalities. b Inhibition of HSF1 with KRIBB11 or CCT251236 enhanced cell death induced by anti-mitosis drugs. CGL2 cells were incubated in media containing KRIBB11 or CCT251236 alone or in combination with an anti-mitosis drug, i.e., Taxol, vinblastine (Vin), or GF-15, at the indicated concentrations for 1 h (a) or 72 h (b). Spindle abnormalities and cell viability were measured at the indicated times. The means ± SD from at least three independent experiments are shown. *p < 0.05 by Student’s t test