Fig. 6

Inhibition of HSF1 transactivation activity enhances cell death-induced by diverse anti-mitosis drugs. CGL2 (a) and MDA-MB-231 (b) cells were incubated in media containing HSF1 inhibitor, KRIBB11 or CCT251236, alone or in combination with anti-mitosis drugs, AZ3146, GSK923295, GF15, or ZM447439. Drugs were treated at the indicated concentrations for 72 h, after which cell viability was measured. The means ± SD from at least three independent experiments are shown. *p < 0.05 by Student’s t test