Fig. 1

Regulation of cell cycle progression from the centrosome. The centrosome plays an important role as a signalling hub during the cell cycle. It facilitates the G1-S transition (top left) and the G2-M transition (bottom left) by recruiting key cell cycle players to the centrosome. The centrosome is also linked to the checkpoint signalling by anchoring the DNA damage checkpoint proteins (right) and the PIDDosome (centre). In the presence of cellular stress such as centrosome amplification and DNA damage, the centrosome promotes the checkpoint responses, which directly or indirectly inhibit the Cdk-Cyclin complexes and arrest the cell cycle