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Fig. 3 | Cell Division

Fig. 3

From: An updated view on the centrosome as a cell cycle regulator

Fig. 3

Crosstalk between two SPB scaffolds demonstrates the integration of signalling to promote cell cycle transitions. a A cartoon depicting the integration of signalling at the yeast SPB. It was previously thought that signalling scaffolds such as Cut12 and Sid4 work independently to promote cell cycle events and are functionally and temporally separated (top). Recent work shows that crosstalk between two functionally distinct signalling scaffolds occurs, working together to promote mitotic entry (bottom). b Model of the centrosomal signalling on Sid4 triggering mitosis. In mid G2, Nek2Fin1 recruits CSNK1DHhp2 by phosphorylating Sid4 at residue T584. Recruitment of CSNK1DHhp2 results in the phosphorylation of residue T275 and S278. This recruits Chk2Cds1 that phosphorylates Cdc14Flp1, expelling the phosphatase from the SPB. The absence of Cdc14Flp1 allows Cdk1-Cyclin B to activate the SPB triggering mitotic entry (CC: coiled-coil domain; SID: Sid domain, conserved N-terminal domain of Sid4)

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