Fig. 1
From: Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis
The process of biosynthesis of miRNA. The miRNA gene is transcribed into pri-miRNA under the action of RNA polymerase II in the nucleus. Pri-miRNA was cut by Drosha and DGCR8 to form pre-miRNA. Pre-miRNA is transported into the cytoplasm through the exportin-5 complex. Pre-miRNA was further cleaved by Dicer enzyme to form double-stranded miRNA. Then one miRNA chain was degraded by AGO2, and the other formed mature miRNA. Mature miRNAs bind to target mRNA