Fig. 6
From: Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis
Mechanism of ncRNA in osteoporosis via the Wnt signaling pathway. miR-181c-5p acts as a sponge-regulated Wnt/β-catenin signaling pathway for the LncRNA, SNHG1; LINC02381 acts as a sponge for miR-21. LINC02381 inhibits the Wnt/β-catenin signaling pathway by absorbing miR-21; CircSmg5 activates the Wnt/β-catenin signaling pathway by targeting the miR-194-5p/Fzd6 axis; Circ_0067680 activates the Wnt/β-catenin signaling pathway by sequestering miR-4429 as a ceRNA, thereby regulating the expression of CTNNB1; The co-regulation mechanism of miRNA by LncRNA and CirRNA remains unknown