Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

An, Fangyu; Meng, Xiangrui; Yuan, Lingqing; Niu, Yanqiang; Deng, Jie; Li, Zhaohui; Liu, Yongqi; Xia, Ruoliu; Liu, Shiqing; Yan, Chunlu

doi:10.1186/s13008-023-00086-7

Cell Division

Table 1 Role and mechanism of ncRNA in osteoporosis

From: Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis

	NcRNA	Effect	Effects on OP	Targeted molecule	Expression of ncRNA in OP	Refs.
MiRNA	MiR-15b	Inhibition of osteoblast differentiation and autophagy	Aggravation	USP7	↑	[80]
	MiR-151a-3p	Reduce the viability of osteoblasts	Aggravation	SOCS5, JAK2/STAT3	↑	[81]
	MiR-483-5p	Promote osteoclast differentiation	Aggravation	NFATC1, NFAT2, CTSK	↑	[82]
	MiR-23a	Inhibit osteogenesis, promote bone resorption and promote inflammatory polarization of macrophages	Aggravation	M-CSF, RANKL	↑	[83]
	MiR-1270	Reduce the proliferation and migration capability of osteoblasts	Aggravation	IRF8	↑	[84]
LncRNA	LncRNA SNHG1	–	Mitigation	–	↓	[85]
	LncRNA PTCSC3	Promote apoptosis of osteoblasts	Aggravation	–	↑	[86]
	LncRNA CAS11	Activation of osteoclasts and increased bone resorption	Aggravation	TNF-α	↑	[87]
	LncRNA WT1-AS	Promote apoptosis of osteoblasts	Aggravation	P53	↑	[88]
	LncRNA AWPPH	Collagen disorder of osteoblasts	Aggravation	–	↑	[89]
	LncRNA XIST	Inhibit osteoblast differentiation	Aggravation	CUL3, Nrf2	↑	[90]
CircRNA	Circ_0005564	Promote bone formation	Mitigation	–	↓	[91]
	Hsa_circ_000127	Promote osteoclast activation	Aggravation	β-CROSSL, OSTEOC, TP1NP	↑	[92]
	Hsa_circ_0001445	–	Mitigation	β-CTx	↓	[93]
Crosstalk regulation	LncRNA ROR/miR-145-5p	Inhibit osteoblast proliferation	Aggravation	ROR	↑	[94]
	LncRNA GAS5/miR-21	Promote osteoclast apoptosis	Mitigation	–	↓	[95]
	LncRNA H19/miR-532-3p	Regulate osteogenic differentiation	Mitigation	SIRT1	↓	[96]
	LncRNA MSC-AS1/miRNA-140-5p	Promote osteoblast differentiation	Mitigation	BMP2	↓	[97]
	Circ_0001795/miR-339-5p	Promote osteoblast differentiation	Mitigation	YAP1	↓	[98]
	CircAtp9b/miR-17-92a	Promote osteoblast apoptosis	Aggravation	–	↑	[99]
	Circ_0019693/miR-942-5p	Promote osteogenic differentiation and angiogenesis coupled with osteogenesis	Mitigation	PCP4	↓	[100]
	Circ_ 0006873/miR-142-5p	Inhibit osteoblast differentiation	Aggravation	PTEN/AKT	↑	[101]

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ISSN: 1747-1028

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