Table 2 Role and mechanism of ncRNA/Wnt in osteoporosis
From: Network regulatory mechanism of ncRNA on the Wnt signaling pathway in osteoporosis
NcRNA/Wnt | Effect | Effects on OP | Key molecule | Expression of ncRNA in OP | Refs. | |
|---|---|---|---|---|---|---|
miRNA/Wnt | miR-23b-3p/Wnt | Inhibit osteoblast differentiation | Aggravation | MRC2 | ↑ | [104] |
miR-146a/Wnt | Inhibit osteoblast differentiation | Aggravation | DKK1 | ↑ | [105] | |
miR-210-3p/Wnt | Promote osteoblast differentiation、inhibit adipogenic differentiation | Mitigation | – | ↓ | [106] | |
miRNA-139-5p/Wnt | Inhibition of cell proliferation、Inhibit osteoblast differentiation | Aggravation | NOTCH1 | ↑ | [107] | |
miR-26b/Wnt | Promote osteoblast differentiation | Mitigation | GSK3β | ↓ | [108] | |
miR-200c/Wnt | Promote osteogenic differentiation and bone formation | Mitigation | Sox2、Klf4 | ↓ | [122] | |
miR-26b/Wnt | Enhanced osteogenic effect | Mitigation | – | ↓ | [124] | |
LncRNA/Wnt | LncRNA HOTAIR/Wnt | Inhibit osteoblast differentiation | Aggravation | – | ↑ | [109] |
LncRNA DANCR/Wnt | Inhibit osteoblast differentiation | Aggravation | – | ↑ | [110] | |
LncRNA AK039312/Wnt | Inhibition of osteoblast differentiation and bone formation | Aggravation | miR-199b-5p、GSK-3β | ↑ | [111] | |
LncRNA AK079370/Wnt | ||||||
LncRNA Crnde/Wnt | Promote osteogenic differentiation | Mitigation | – | ↓ | [112] | |
LncRNA p21/Wnt | Inhibit osteoblast differentiation | Aggravation | E2 | ↑ | [113] | |
CircRNA/Wnt | circ_0024097/Wnt | Promote osteogenic differentiation | Mitigation | YAP1 | ↓ | [114] |
Circ_ FBLN1/Wnt | Promote osteoblast differentiation | Mitigation | FZD4 | ↓ | [115] | |
circStag1/Wnt | Promote osteoblast differentiation | Mitigation | Lrp5/6 | ↓ | [116] | |
Crosstalk regulation | LncRNA SNHG1/miR-181c-5p/Wnt | Inhibit osteoblast differentiation and angiogenesis,、 promote osteoclast formation | Aggravation | SFRP1 | ↑ | [117] |
LncRNA SNHG1/miR-101/Wnt | Inhibition osteoblast differentiation | Aggravation | DKK1 | ↑ | [118] | |
LINC02381/miR-21/Wnt | Inhibition osteoblast differentiation | Aggravation | KLF12 | ↑ | [119] | |
LNC-H19/miR-141/Wnt | Promote osteoblast differentiation | Mitigation | – | ↓ | [123] | |
LNC-H19/miR-22/Wnt | ||||||
CircSmg5/miR-194-5p/Wnt | Promote osteoblast differentiation | Mitigation | Lrp5/6 | ↓ | [120] | |
Circ_0067680/miR-4429/Wnt | Promote osteoblast differentiation | Mitigation | CTNNB1 | ↓ | [121] |