Fig. 8From: Sustained Shugoshin 1 downregulation reduces tumor growth and metastasis in a mouse xenograft tumor model of triple-negative breast cancerResearch model. Diagram summarizing our findings that SGO1 modulates Snail and Slug expression, which in turn leads to EMT through the repression of epithelial markers and activates mesenchymal markers, including MMPs. In turn, these molecular changes act as precursors to cell invasion, cell migration, and metastasis in TNBCBack to article page