From: Tying the loose ends together in DNA double strand break repair with 53BP1
Defective Gene(s) | B cell lymphoma | T cell lymphoma | References |
---|---|---|---|
53BP1 | None | Low-mild | [29, 69] |
p53 | None | All aneuploid with no clonal breaks | [109–111] |
53BP1/p53 | t(12;15) translocations that amplify c-myc | Aneuploidy and clonal translocations that include TCRα locus | [14, 85] |
H2AX | None | Low-mild | [73, 74] |
H2AX/p53 | t(12;15) translocations that amplify c-myc | 75% of animals clonal translocations; H2AX+/- p53-/- animals are aneuploid or possess clonal translocations | [71, 72] |
NHEJ | None | None | [77] |
NHEJ/p53 | Pro-B cell lymphoma | None | [77, 89–92] |
Mdc1 | None | Low | [39] |
ATM | None | 100% of animals with clonal translocations at TCR locus of chromosome 14 | [75] |