Figure 2

Progression through the different stages of mitosis in Lzts1^+/+ and Lzts1^-/- cells. During prophase the interaction between Lzts1 and Cdc25C allows high levels of Cdc25C expression and activity resulting in normal progression from prophase to metaphase. In Lzts1 deficient cell during prophase, Cdc25C is rapidly ubiquitinated and degraded thus determining a low activity of the cyclin B1/Cdk1 complex. As a consequence the cell progress faster through prophase and prometaphase and frequently undergo to chromosomes missegregation. Yellow arrows indicate lagging chromosomes in Lzts1^-/- cells.