Table 1 SUMO Pathway Enzymes
Enzymatic activity | Vertebrate | S. cerevisiae | S. pombe |
|---|---|---|---|
SUMO paralogues | SUMO1 | Smt3p | Pmt3p |
| Â | SUMO2 | Â | Â |
| Â | SUMO3 | Â | Â |
SUMO protease | SENP1-3, SENP5-7 | Ulp1p | Ulp1 |
| Â | Â | Ulp2p/Smt4p | Ulp2 |
Activating Enzyme (E1) | Uba2/SAE2 +Aos1/SAE1 | Uba2p+Aos1p | Uba2/Fub2 + Rad31 |
Conjugating Enzyme (E2) | Ubc9 | Ubc9p | Hus5p |
SP-RING SUMO ligases (E3) | PIAS1 | Siz1p | Pli1 |
| Â | PIAS3 | Siz2p/Nfi1p, | Â |
|  | PIASxα |  |  |
|  | PIASxβ |  |  |
| Â | PIASy | Â | Â |
| Â | Mms21 | Mms21p | Nse2p |
| Â | Â | Zip3p | Â |
| Â | Zimp7* | Â | Â |
| Â | Zimp10* | Â | Â |
Other SUMO ligases (E3) | RanBP2 | (None known) | (None known) |
| Â | Pc2 | Â | Â |