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Table 2 Combined disruption of Dido and DNA-PKcs.

From: Merotelic attachments and non-homologous end joining are the basis of chromosomal instability

DNA-PKcs

Dido

N° pups (expected)

N° pups (observed)

+/+

+/+

60.25

100

+/+

+/neo

120.50

162

+/+

neo/neo

60.25

22

+/-

+/+

120.50

122

+/-

+/neo

241.00

273

+/-

neo/neo

120.50

40

-/-

+/+

60.25

56

-/-

+/neo

120.50

169

-/-

neo/neo

60.25

20

Total

964

964

  1. Mice heterozygous for Dido and DNA-PKcs were crossed and all viable pups were genotyped. Whereas the numbers of wild-type, heterozygous and DNA-PKcs mutant mice born are as expected, Dido and Dido DNA-PKcs mutant mouse numbers were below the expected frequency.
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Cell Division

ISSN: 1747-1028

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