Figure 13From: Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner Smurf2 knockdown modulates the PI3K-AKT signaling pathway in a CNKSR2 dependent manner. Smurf2 knockdown diminishes Akt phosphorylation and FoxO3a-dependent cell proliferation. Lysates from control siRNA and Smurf2 siRNA treated MDA-MB-231 cells were probed with the indicated antibodies. β-actin was used as the loading control.Back to article page