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Table 5 Thirty-one hub genes with a degree of ≥ 15 in the protein–protein interaction network

From: Microarray expression profile of mRNAs and long noncoding RNAs and the potential role of PFK-1 in infantile hemangioma

Gene ID

Fold Change

P-value

Feature

Out Degree

In Degree

Total Degree

Rank

NOTCH1

1.505646

0.000815

Up

13

22

35

1

COL1A1

1.530545

0.047257

Up

20

10

30

2

CYCS

− 1.645191

0.007507

Down

7

19

26

3

COL4A1

2.501585

0.002376

Up

19

4

23

4

ACTA2

1.609589

0.029662

Up

21

1

22

5

PDGFRB

1.982871

0.000202

Up

3

18

21

6

KDR

2.478637

0.022919

Up

4

17

21

7

MMP14

1.646649

0.001126

Up

9

12

21

8

ELN

1.559719

0.029079

Up

11

10

21

9

ITGA5

1.859768

0.002024

Up

8

12

20

10

PPP1CC

− 1.611769

0.005672

Down

6

13

19

11

UBE2D1

− 2.344914

0.002874

Down

13

6

19

12

PPP1CB

− 1.590005

0.005132

Down

16

3

19

13

BGN

1.619226

0.012656

Up

8

10

18

14

COL4A2

2.395693

0.000766

Up

16

2

18

15

DLD

− 1.877071

0.001431

Down

0

17

17

16

TLN1

1.548241

0.001011

Up

5

12

17

17

COL6A2

1.539987

0.002659

Up

8

9

17

18

FLNA

1.699094

0.000618

Up

12

5

17

19

ACTN1

1.506622

0.012742

Up

13

4

17

20

ENG

1.567089

0.00081

Up

15

2

17

21

THY1

1.920826

0.007751

Up

6

10

16

22

COL18A1

1.582594

0.000192

Up

11

5

16

23

CUL2

− 1.5414

0.013956

Down

16

0

16

24

NDUFB5

− 1.639639

0.004704

Down

2

13

15

25

MYL9

1.622037

0.02276

Up

3

12

15

26

UBE2B

− 1.61738

0.001153

Down

4

11

15

27

LRRK2

− 1.80695

0.001503

Down

7

8

15

28

CUL5

− 1.900919

0.007236

Down

10

5

15

29

ACADM

− 1.721258

0.003933

Down

11

4

15

30

ACTG2

1.564071

0.026988

Up

13

2

15

31