Fig. 1

SGO1 downregulation reduces tumor growth. The average of left and right tumors per day for the shRNA Control group (n = 10) and the shRNA SGO1 group (n = 10) were recorded for 45 days post-injection (a). The error bars represent the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 were considered statistically significant. A two-way ANOVA was conducted to compare differences between groups with more than one categorical variable. Some representative images of the primary tumors per each group are shown (b). A Western blot was performed to characterize the SGO1 expression in representative primary tumors (c). The densitometry analysis is shown (d). The error bars represent the mean ± SEM. *p < 0.05, **p < 0.01, and ***p < 0.001 were considered statistically significant. N.S. stands for not significant. A Student t-test (unpaired, two-tailed) was used to compare differences between groups