SIRT4 is an independent prognostic factor in bladder cancer and inhibits bladder cancer growth by suppressing autophagy

Table 3 Cox multivariate analyses of prognostic factors for overall survival

Variables	HR	95% CI	P value^a
Tumor size (cm) (≤ 5 versus > 5)	0.53	0.22–1.28	0.16
Differentiation (I-II versus III-IV)	1.89	0.77–4.68	0.17
T stage (T1-T2 versus T3-T4)	1.95	0.57–6.67	0.29
N stage (N0 versus N1-N2)	1.83	0.58–5.70	0.30
AJCC stage (I-II versus III-IV)	0.97	0.27–3.50	0.96
SIRT4 levels (high versus low)	2.551	1.07–6.07	0.03

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