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Fig. 7 | Cell Division

Fig. 7

From: The roles of METTL3 on autophagy and proliferation of vascular smooth muscle cells are mediated by mTOR rather than by CDK1

Fig. 7

The indispensable role of mTOR in METTL3 regulation of autophagy and proliferation in VSMC. In VSMC, the inhibitory effect of METTL3 on proliferation by enhancing autophagosome formation is mediated by mTOR activation. The mTOR inhibitor, rapamycin, offsets the impacts of METTL3 knockdown on autophagy and proliferation. Similarly, MHY1485 counteracts the effects of METTL3 on VSMC autophagy and proliferation by activating mTOR

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Cell Division

ISSN: 1747-1028

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