Fig. 5
From: Slik maintains tissue homeostasis by preventing JNK-mediated apoptosis
slik is physiologically required for proper tissue homeostasis in development. Merged fluorescence micrographs of Drosophila third instar larval wing discs are shown (A–C, E–G, I–K). From the Flp-out clones (marked by GFP), compared with the control (A), slik knockdown clones (GFP+) displayed decreased clonal size (B), which was rescued by expressing BskDN (C). Statistical analysis of clone size/total size ratio in A–C are shown (D, n = 10 for each group). Besides, compared with the en-Gal4 (E) and nub-Gal4 controls (I), slik depletion-evoked decreased GFP area in the posterior compartment F or the whole wing pouch J was restored by BskDN (G, K). Statistical analysis of GFP+ area/GFP− area ratio in E–G (H, n = 10 for each group) and I-K (L, n = 11; n = 8; n = 7) are shown. One-way ANOVA with Bonferroni multiple-comparison test was used to compute P-values, ****P < 0.0001, ***p < 0.001, *P < 0.05, n.s indicates not significant. See the supplementary material for detailed genotypes. Scale bar: 100 μm