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Fig. 4 | Cell Division

Fig. 4

From: Preeclampsia-associated lncRNA FEZF1-AS1 regulates cell proliferation and apoptosis in placental trophoblast cells through the ELAVL1/NOC2L axis

Fig. 4

The interaction between FEZF1-AS1 and ELAVL1 increased the stability of NOC2L mRNA. FEZF1-AS1 was knocked down or overexpressed in HTR-8/SVneo cell lines, grouped as follows: si-NC, si-FEZF1-AS1, oe-NC, and oe-FEZF1-AS1. A, B The mRNA and protein expression levels of NOC2L were detected by qPCR and western blot techniques. ELAVL1 was knocked down or overexpressed in HTR-8/SVneo cell lines, grouped as follows: si-NC, si-ELAVL1, oe-NC, and oe-ELAVL1. C, D The mRNA and protein expression of NOC2L and ELAVL1 were detected by qPCR and western blot assays. FEZF1-AS1 and/or ELAVL1 were knocked down in HTR-8/SVneo cell lines and grouped as follows: si-NC, si-FEZF1-AS1, si-ELAVL1, and si-FEZF1-AS1 + si-ELAVL1. E The effects of FEZF1-AS1 and ELAVL1 on the stability of NOC2L mRNA were detected by qPCR. n = 3, *p < 0.05, **p < 0.01, ***p < 0.001

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Cell Division

ISSN: 1747-1028

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