Fig. 6

GDF15 is co-expressed with GPX4 and promotes ferroptosis. A. Western blotting images showing the effect of GDF15 knockdown on GPX4 expression in 769-p and Caki-1 cell lines. B. Western blotting images showing the effect of GDF15 forced over-expression on GPX4 expression in 769-p and Caki-1 cell lines. C, D. Line plots showing the results of cell proliferation in GDF15-overexpressed 769-p (C) and Caki-1 cells (D). E Schematic diagram of the molecular mechanisms linking GDF15 to ferroptosis. * p < 0.05, ** p < 0.01, *** p < 0.001