Fig. 3

The abundance of ZNF468 confers the cytotoxicity of cisplatin to BC cells. A Ctrl and ZNF468 overexpressing MCF-7 cells were incubated with vehicle or different concentrations (1, 5, 10 and 20 μM) of cisplatin for 48 h. Cell viability was detected by CCK-8 assay. *p < 0.05. **p < 0.01. B siCtrl, siZNF468#1 and siZNF468#2 MDA-MB-231 cells were treated with vehicle or different concentrations (1, 5, 10 and 20 μM) of cisplatin for 48 h. Cell viability was detected by CCK-8 assay. *p < 0.05. **p < 0.01. C, D Ctrl and ZNF468 overexpressing MCF-7 cells were incubated with vehicle or 10 μM of cisplatin. Conoly formation was detected 10 days later. *p < 0.05. **p < 0.01. E, F siCtrl, siZNF468#1 and siZNF468#2 MDA-MB-231 cells were incubated with vehicle or 10 μM of cisplatin. Conoly formation was detected 7 days later. *p < 0.05. **p < 0.01