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Fig. 3 | Cell Division

Fig. 3

From: GSDMD induces hepatocyte pyroptosis to trigger alcoholic hepatitis through modulating mitochondrial dysfunction

Fig. 3

Alcohol causes mitochondrial dysfunction in hepatocytes in AH. Alcoholic hepatitis (AH) mouse model was induced by administering alcohol via gavage directly into the animal's stomach in normal mice. At the endpoint of each experiment, the blood and liver tissues were collected. A The gene expression of ND1 and ND2 in liver tissues of control or AH mice were measured by qPCR. B The level of ATP in liver tissues of control or AH mice were measured by ATP kits. C The expression levels of Mfn1, Mfn2, Opa1, Drp1, and Fis1 in liver tissues of control or AH mice were measured by western blot. Data are presented as mean ± SD (n = 6 mice per group). Unpaired t-test was performed for statistical analysis. **p < 0.01. D The mitochondria structure of hepatocytes in liver tissues of control or AH mice was imaged by TEM.

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Cell Division

ISSN: 1747-1028

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