Fig. 5
From: CIP/KIP and INK4 families as hostages of oncogenic signaling
A Graphic illustrating the role of p16INK4a in normal cells (left cellular part) and in transformed cells (right cellular part). The graphics focuses on major posttranslational modifications altering the function of p16INK4a and depicting major oncogenic pathways responsible for inactivation or gain-of-function modifications. Created with BioRender.com. B p16INK4a domain structure with highlighted sites of posttranslational modifications