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  1. Research

    The subunits of the S-phase checkpoint complex Mrc1/Tof1/Csm3: dynamics and interdependence

    The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM ...

    Sonya Dimitrova Uzunova, Alexander Stefanov Zarkov, Anna Marianova Ivanova, Stoyno Stefanov Stoynov and Marina Nedelcheva Nedelcheva-Veleva

    Cell Division 2014 9:4

    Published on: 31 October 2014

  2. Research

    Smurf2 E3 ubiquitin ligase modulates proliferation and invasiveness of breast cancer cells in a CNKSR2 dependent manner

    Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Sm...

    Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Sivakumari Nair and Radhakrishna Madhavan Pillai

    Cell Division 2014 9:2

    Published on: 31 August 2014

  3. Short report

    The DNA repair component Metnase regulates Chk1 stability

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray, Suk-Hee Lee, Jac A Nickoloff and Robert Hromas

    Cell Division 2014 9:1

    Published on: 9 July 2014

  4. Review

    The COP9 signalosome subunit 6 (CSN6): a potential oncogene

    CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repres...

    Shang-Nuan Zhang, Dong-Sheng Pei and Jun-Nian Zheng

    Cell Division 2013 8:14

    Published on: 28 November 2013

  5. Research

    A pool of peptides extracted from wheat bud chromatin inhibits tumor cell growth by causing defective DNA synthesis

    We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...

    Loretta Mancinelli, Teresa Secca, Paula M De Angelis, Francesco Mancini, Matteo Marchesini, Cristiano Marinelli, Lanfranco Barberini and Francesco Grignani

    Cell Division 2013 8:11

    Published on: 6 August 2013

  6. Research

    Silencing CDK4 radiosensitizes breast cancer cells by promoting apoptosis

    The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...

    Katie R Hagen, Xiangbin Zeng, Mi-Young Lee, Shannon Tucker Kahn, Mary Kathryn Harrison Pitner, Sandra S Zaky, Yuan Liu, Ruth M O’Regan, Xingming Deng and Harold I Saavedra

    Cell Division 2013 8:10

    Published on: 25 July 2013

  7. Research

    Mutually dependent degradation of Ama1p and Cdc20p terminates APC/C ubiquitin ligase activity at the completion of meiotic development in yeast

    The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity ...

    Grace S Tan, Rebecca Lewandowski, Michael J Mallory, Randy Strich and Katrina F Cooper

    Cell Division 2013 8:9

    Published on: 1 July 2013

  8. Review

    To divide or not to divide: revisiting liver regeneration

    The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration...

    Yuichiro Miyaoka and Atsushi Miyajima

    Cell Division 2013 8:8

    Published on: 20 June 2013

  9. Research

    Cell cycle-dependent localization of CHK2 at centrosomes during mitosis

    Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers wher...

    Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Francis Rodier and Estelle Schmitt

    Cell Division 2013 8:7

    Published on: 16 May 2013

  10. Methodology

    A 2D/3D image analysis system to track fluorescently labeled structures in rod-shaped cells: application to measure spindle pole asymmetry during mitosis

    The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by...

    Daniel Schmitter, Paulina Wachowicz, Daniel Sage, Anastasia Chasapi, Ioannis Xenarios, Viesturs Simanis and Michael Unser

    Cell Division 2013 8:6

    Published on: 27 April 2013

  11. Research

    Proteolysis of Xenopus Cip-type CDK inhibitor, p16Xic2, is regulated by PCNA binding and CDK2 phosphorylation

    Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been des...

    Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller and P Renee Yew

    Cell Division 2013 8:5

    Published on: 22 April 2013

  12. Research

    Rad53 homologue forkhead-associated kinase A (FhkA) and Ca2+-binding protein 4a (CBP4a) are nucleolar proteins that differentially redistribute during mitosis in Dictyostelium

    During mitosis most nucleolar proteins redistribute to other locales providing an opportunity to study the relationship between nucleolar protein localization and function. Dictyostelium is a model organism for t...

    Andrew Catalano and Danton H O’Day

    Cell Division 2013 8:4

    Published on: 12 April 2013

  13. Commentary

    Ndc80 Loop as a protein-protein interaction motif

    Our understanding of the structure and function of kinetochores has advanced dramatically over the past 10 years, yet how the plus end of spindle microtubules interacts with the kinetochore and establishes amp...

    Ngang Heok Tang and Takashi Toda

    Cell Division 2013 8:2

    Published on: 15 March 2013

  14. Research

    Identification of new cell size control genes in S. cerevisiae

    Cell size homeostasis is a conserved attribute in many eukaryotic species involving a tight regulation between the processes of growth and proliferation. In budding yeast S. cerevisiae, growth to a “critical cell...

    Huzefa Dungrawala, Hui Hua, Jill Wright, Lesley Abraham, Thivakorn Kasemsri, Anthony McDowell, Jessica Stilwell and Brandt L Schneider

    Cell Division 2012 7:24

    Published on: 12 December 2012

  15. Methodology

    Replication of somatic micronuclei in bovine enucleated oocytes

    Microcell-mediated chromosome transfer (MMCT) was developed to introduce a low number of chromosomes into a host cell. We have designed a novel technique combining part of MMCT with somatic cell nuclear transf...

    Natalia Canel, Romina Bevacqua, María Inés Hiriart and Daniel Salamone

    Cell Division 2012 7:23

    Published on: 22 November 2012

  16. Review

    Emerging players in the initiation of eukaryotic DNA replication

    Faithful duplication of the genome in eukaryotes requires ordered assembly of a multi-protein complex called the pre-replicative complex (pre-RC) prior to S phase; transition to the pre-initiation complex (pre...

    Zhen Shen and Supriya G Prasanth

    Cell Division 2012 7:22

    Published on: 17 October 2012

  17. Research

    Epitope of titin A-band-specific monoclonal antibody Tit1 5 H1.1 is highly conserved in several Fn3 domains of the titin molecule. Centriole staining in human, mouse and zebrafish cells

    Previously we have reported on the development of a new mouse anti-titin monoclonal antibody, named MAb Titl 5 H1.1, using the synthetic peptide N-AVNKYGIGEPLESDSVVAK-C which corresponds to an amino acid seque...

    Aavo-Valdur Mikelsaar, Alar Sünter, Ruth Mikelsaar, Peeter Toomik, Anu Kõiveer, Imre Mikelsaar and Erkki Juronen

    Cell Division 2012 7:21

    Published on: 17 September 2012

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