Table 2 Sld2 orthologues
From: The role of CDK in the initiation step of DNA replication in eukaryotes
Species | Gene product | Features |
|---|---|---|
S. cerevisiae | Sld2/Drc1 | Phosphorylation at T84 by CDK is essential for initiation. Phosphorylated Sld2 binds Dpb11 C-terminus. Alanine-substitution mutant is lethal. [7, 12] |
S. pombe | Drc1 | Phosphorylation by CDK is essential for initiation. Alanine-substitution mutant is lethal. [26] |
X. laevis | RTS/RecQ4 | N-terminal portion show similarity to Sld2. C-terminal portion has RecQ helicase motif. It binds Cut5 and is required for DNA replication. [36] |
H. sapiens M.musculus | RTS/RecQL4 | N-terminal portion show similarity to Sld2. C-terminal portion has RecQ helicase motif. It is essential for cell proliferation. Rothmund-Thomson syndrome and Rapadilino syndrome cells have mutaions in this gene. [36] |