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Table 2 Sld2 orthologues

From: The role of CDK in the initiation step of DNA replication in eukaryotes

Species Gene product Features
S. cerevisiae Sld2/Drc1 Phosphorylation at T84 by CDK is essential for initiation.
Phosphorylated Sld2 binds Dpb11 C-terminus.
Alanine-substitution mutant is lethal. [7, 12]
S. pombe Drc1 Phosphorylation by CDK is essential for initiation.
Alanine-substitution mutant is lethal. [26]
X. laevis RTS/RecQ4 N-terminal portion show similarity to Sld2. C-terminal portion has RecQ helicase motif. It binds Cut5 and is required for DNA replication. [36]
H. sapiens M.musculus RTS/RecQL4 N-terminal portion show similarity to Sld2. C-terminal portion has RecQ helicase motif. It is essential for cell proliferation.
Rothmund-Thomson syndrome and Rapadilino syndrome cells have mutaions in this gene. [36]