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Hypothesis
The varied nature of human cancers is recapitulated, at least to some extent, in the diverse NCI-60 panel of human cancer cell lines. Here, I used a basic, continuous variable of proliferating cells, their dou...
Cell Division 2017 12:6
Published on: 29 August 2017
Erratum
Cell Division 2017 12:5
Published on: 18 July 2017
The original article was published in Cell Division 2016 11:10
Erratum
Cell Division 2017 12:4
Published on: 3 July 2017
The original article was published in Cell Division 2016 11:14
Research
The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle.
Cell Division 2017 12:3
Published on: 14 March 2017
Commentary
Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure...
Cell Division 2017 12:2
Published on: 6 January 2017
Research
Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it...
Cell Division 2017 12:1
Published on: 3 January 2017
Commentary
Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet...
Cell Division 2016 11:14
Published on: 28 October 2016
The Erratum to this article has been published in Cell Division 2017 12:4
Erratum
Cell Division 2016 11:13
Published on: 6 October 2016
The original article was published in Cell Division 2011 6:7
Review
The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve...
Cell Division 2016 11:12
Published on: 27 September 2016
Research
Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and t...
Cell Division 2016 11:11
Published on: 2 August 2016
Research
The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt...
Cell Division 2016 11:10
Published on: 29 July 2016
The Erratum to this article has been published in Cell Division 2017 12:5
Review
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as c...
Cell Division 2016 11:9
Published on: 13 July 2016
Review
Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process...
Cell Division 2016 11:8
Published on: 10 June 2016
Review
Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and...
Cell Division 2016 11:7
Published on: 23 May 2016
Research
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...
Cell Division 2016 11:6
Published on: 22 April 2016
Review
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional module...
Cell Division 2016 11:5
Published on: 1 April 2016
Review
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...
Cell Division 2016 11:4
Published on: 31 March 2016
Research
The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow durin...
Cell Division 2016 11:3
Published on: 18 March 2016
Review
Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly conce...
Cell Division 2016 11:2
Published on: 9 March 2016
Review
The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...
Cell Division 2016 11:1
Published on: 9 March 2016
Review
Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...
Cell Division 2015 10:6
Published on: 12 October 2015
Research
Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...
Cell Division 2015 10:5
Published on: 11 August 2015
Review
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel...
Cell Division 2015 10:4
Published on: 20 June 2015
Review
Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of mutations conferring aggressive or drug-resistant phenotypes during cancer evolution. Chromosomal instability (CIN) i...
Cell Division 2015 10:3
Published on: 20 May 2015
Short report
CDKN1C (also known as P57 kip2 ) is a cyclin-dependent kinase inhibitor that functions as a negative regulator of cell proliferation through G1 ...
Cell Division 2015 10:2
Published on: 28 March 2015
