Erratum
Cell Division 2017 12:5
Published on: 18 July 2017
The original article was published in Cell Division 2016 11:10
Articles
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Erratum
Cell Division 2017 12:4
Published on: 3 July 2017
The original article was published in Cell Division 2016 11:14
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Research
Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control
The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle.
Cell Division 2017 12:3
Published on: 14 March 2017
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Commentary
Systematic epistatic mapping of cellular processes
Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure...
Cell Division 2017 12:2
Published on: 6 January 2017
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Research
The Irr1/Scc3 protein implicated in chromosome segregation in Saccharomyces cerevisiae has a dual nuclear-cytoplasmic localization
Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it...
Cell Division 2017 12:1
Published on: 3 January 2017
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Commentary
Electrostatic forces drive poleward chromosome motions at kinetochores
Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet...
Cell Division 2016 11:14
Published on: 28 October 2016
The Erratum to this article has been published in Cell Division 2017 12:4
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Erratum
Cell Division 2016 11:13
Published on: 6 October 2016
The original article was published in Cell Division 2011 6:7
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Review
The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway
The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve...
Cell Division 2016 11:12
Published on: 27 September 2016
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Research
Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways
Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and t...
Cell Division 2016 11:11
Published on: 2 August 2016
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Research
Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae
The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt...
Cell Division 2016 11:10
Published on: 29 July 2016
The Erratum to this article has been published in Cell Division 2017 12:5
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Review
Insights into APC/C: from cellular function to diseases and therapeutics
Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as c...
Cell Division 2016 11:9
Published on: 13 July 2016
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Review
Cullin-RING ligases in regulation of autophagy
Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process...
Cell Division 2016 11:8
Published on: 10 June 2016
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Review
The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions
Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and...
Cell Division 2016 11:7
Published on: 23 May 2016
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Research
The T-box transcription factor TBX3 drives proliferation by direct repression of the p21WAF1 cyclin-dependent kinase inhibitor
TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...
Cell Division 2016 11:6
Published on: 22 April 2016
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Review
Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications
Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional module...
Cell Division 2016 11:5
Published on: 1 April 2016
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Review
New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics
PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...
Cell Division 2016 11:4
Published on: 31 March 2016
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Research
Mitochondria-cytoskeleton associations in mammalian cytokinesis
The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow durin...
Cell Division 2016 11:3
Published on: 18 March 2016
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Review
The role of cullin 5-containing ubiquitin ligases
The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...
Cell Division 2016 11:1
Published on: 9 March 2016
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Review
C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response
Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly conce...
Cell Division 2016 11:2
Published on: 9 March 2016
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Review
Curcumin and tumor immune-editing: resurrecting the immune system
Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...
Cell Division 2015 10:6
Published on: 12 October 2015
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Research
COP9-Signalosome deneddylase activity is enhanced by simultaneous neddylation: insights into the regulation of an enzymatic protein complex
Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...
Cell Division 2015 10:5
Published on: 11 August 2015
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Review
Sumo and the cellular stress response
The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel...
Cell Division 2015 10:4
Published on: 20 June 2015
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Review
Aneuploidy and chromosomal instability in cancer: a jackpot to chaos
Genomic instability (GIN) is a hallmark of cancer cells that facilitates the acquisition of mutations conferring aggressive or drug-resistant phenotypes during cancer evolution. Chromosomal instability (CIN) i...
Cell Division 2015 10:3
Published on: 20 May 2015
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Short report
Mutations in the PCNA-binding site of CDKN1C inhibit cell proliferation by impairing the entry into S phase
CDKN1C (also known as P57 kip2 ) is a cyclin-dependent kinase inhibitor that functions as a negative regulator of cell proliferation through G1 ...
Cell Division 2015 10:2
Published on: 28 March 2015
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Short report
Cyclin E2 is the predominant E-cyclin associated with NPAT in breast cancer cells
The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesis, ...
Cell Division 2015 10:1
Published on: 19 February 2015
