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  1. Content type: Review

    Aurora kinases are serine/threonine kinases essential for the onset and progression of mitosis. Aurora members share a similar protein structure and kinase activity, but exhibit distinct cellular and subcellul...

    Authors: Estelle Willems, Matthias Dedobbeleer, Marina Digregorio, Arnaud Lombard, Paul Noel Lumapat and Bernard Rogister

    Citation: Cell Division 2018 13:7

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  2. Content type: Methodology

    Live-cell fluorescence microscopy (LCFM) is a powerful tool used to investigate cellular dynamics in real time. However, the capacity to simultaneously measure DNA content in cells being tracked over time rema...

    Authors: Cecil J. Gomes, Michael W. Harman, Sara M. Centuori, Charles W. Wolgemuth and Jesse D. Martinez

    Citation: Cell Division 2018 13:6

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  3. Content type: Research

    Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo GTP biosynthesis, plays an important role in cell metabolism and proliferation. It has been demonstrated that IMPDH can aggregat...

    Authors: Gerson Dierley Keppeke, Chia Chun Chang, Min Peng, Li-Yu Chen, Wei-Cheng Lin, Li-Mei Pai, Luis Eduardo Coelho Andrade, Li-Ying Sung and Ji-Long Liu

    Citation: Cell Division 2018 13:5

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  4. Content type: Research

    Kinesin superfamily proteins are microtubule-based molecular motors essential for the intracellular transport of various cargos, including organelles, proteins, and RNAs. However, their exact roles during mamm...

    Authors: Yan Xie, Minghui Cheng, Shan Lu, Qilong Yuan, Dongyu Yang, Ying Chen, Chen Pan, Yurong Qiu and Bo Xiong

    Citation: Cell Division 2018 13:4

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  5. Content type: Commentary

    Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate...

    Authors: Steven Boeynaems, Peter Tompa and Ludo Van Den Bosch

    Citation: Cell Division 2018 13:1

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  6. Content type: Review

    Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested ext...

    Authors: Hana Paculová and Jiří Kohoutek

    Citation: Cell Division 2017 12:7

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  7. Content type: Research

    The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle.

    Authors: Michael J. Thwaites, Matthew J. Cecchini, Srikanth Talluri, Daniel T. Passos, Jasmyne Carnevale and Frederick A. Dick

    Citation: Cell Division 2017 12:3

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  8. Content type: Commentary

    Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure...

    Authors: Maximilian Billmann and Michael Boutros

    Citation: Cell Division 2017 12:2

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  9. Content type: Research

    Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it...

    Authors: Piotr Kowalec, Jan Fronk and Anna Kurlandzka

    Citation: Cell Division 2017 12:1

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  10. Content type: Commentary

    Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet...

    Authors: L. John Gagliardi and Daniel H. Shain

    Citation: Cell Division 2016 11:14

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    The Erratum to this article has been published in Cell Division 2017 12:4

  11. Content type: Review

    The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve...

    Authors: Humberto Contreras-Cornejo, Germán Saucedo-Correa, Javier Oviedo-Boyso, Juan José Valdez-Alarcón, Víctor Manuel Baizabal-Aguirre, Marcos Cajero-Juárez and Alejandro Bravo-Patiño

    Citation: Cell Division 2016 11:12

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  12. Content type: Research

    Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and t...

    Authors: Siraj M. El Jamal, Erin B. Taylor, Zakaria Y. Abd Elmageed, Abdulhadi A. Alamodi, Denis Selimovic, Abdulaziz Alkhateeb, Matthias Hannig, Sofie Y. Hassan, Simeon Santourlidis, Paul L. Friedlander, Youssef Haikel, Srinivasan Vijaykumar, Emad Kandil and Mohamed Hassan

    Citation: Cell Division 2016 11:11

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  13. Content type: Research

    The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt...

    Authors: Stephen J. Kim and Randy Strich

    Citation: Cell Division 2016 11:10

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    The Erratum to this article has been published in Cell Division 2017 12:5

  14. Content type: Review

    Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process...

    Authors: Danrui Cui, Xiufang Xiong and Yongchao Zhao

    Citation: Cell Division 2016 11:8

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  15. Content type: Research

    TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...

    Authors: Tarryn Willmer, Shannagh Hare, Jade Peres and Sharon Prince

    Citation: Cell Division 2016 11:6

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  16. Content type: Review

    PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...

    Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen and Yong Wan

    Citation: Cell Division 2016 11:4

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  17. Content type: Review

    The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...

    Authors: Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa and Takumi Kamura

    Citation: Cell Division 2016 11:1

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  18. Content type: Review

    Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...

    Authors: Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee and Gaurisankar Sa

    Citation: Cell Division 2015 10:6

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  19. Content type: Research

    Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...

    Authors: Gil Bornstein and Chagai Grossman

    Citation: Cell Division 2015 10:5

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  20. Content type: Review

    The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel...

    Authors: Jorrit M. Enserink

    Citation: Cell Division 2015 10:4

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  21. Content type: Short report

    The cyclin E oncogene activates CDK2 to drive cells from G1 to S phase of the cell cycle to commence DNA replication. It coordinates essential cellular functions with the cell cycle including histone biogenesis, ...

    Authors: Samuel Rogers, Brian S Gloss, Christine S Lee, Claudio Marcelo Sergio, Marcel E Dinger, Elizabeth A Musgrove, Andrew Burgess and Catherine Elizabeth Caldon

    Citation: Cell Division 2015 10:1

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  22. Content type: Research

    Heterochromatin protein 1 (HP1) is important in the establishment, propagation, and maintenance of constitutive heterochromatin, especially at the pericentromeric region. HP1 might participate in recruiting an...

    Authors: Rodrigo González-Barrios, Ernesto Soto-Reyes, Ricardo Quiroz-Baez, Eunice Fabián-Morales, José Díaz-Chávez, Victor del Castillo, Julia Mendoza, Alejandro López-Saavedra, Clementina Castro and Luis A Herrera

    Citation: Cell Division 2014 9:6

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  23. Content type: Commentary

    Recent experiments revealing nanoscale electrostatic force generation at kinetochores for chromosome motions have prompted models for interactions between positively charged molecules in kinetochores and negat...

    Authors: Lucian John Gagliardi and Daniel H Shain

    Citation: Cell Division 2014 9:5

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  24. Content type: Research

    The S-phase checkpoint aims to prevent cells from generation of extensive single-stranded DNA that predisposes to genome instability. The S. cerevisiae complex Tof1/Csm3/Mrc1 acts to restrain the replicative MCM ...

    Authors: Sonya Dimitrova Uzunova, Alexander Stefanov Zarkov, Anna Marianova Ivanova, Stoyno Stefanov Stoynov and Marina Nedelcheva Nedelcheva-Veleva

    Citation: Cell Division 2014 9:4

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  25. Content type: Research

    Centrosome amplification (CA) amongst particular breast cancer subtypes (Her2+ subtype) is associated with genomic instability and aggressive tumor phenotypes. However, changes in signaling pathways associated...

    Authors: Mi-Young Lee, Mihaela Marina, Jamie L King and Harold I Saavedra

    Citation: Cell Division 2014 9:3

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  26. Content type: Research

    Smurf2 is a member of the HECT family of E3 ubiquitin ligases that play important roles in determining the competence of cells to respond to TGF- β/BMP signaling pathway. However, besides TGF-β/BMP pathway, Sm...

    Authors: Diana David, Sankar Jagadeeshan, Ramkumar Hariharan, Asha Sivakumari Nair and Radhakrishna Madhavan Pillai

    Citation: Cell Division 2014 9:2

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  27. Content type: Short report

    Chk1 both arrests replication forks and enhances repair of DNA damage by phosphorylation of downstream effectors. Metnase (also termed SETMAR) is a SET histone methylase and transposase nuclease protein that p...

    Authors: Elizabeth A Williamson, Yuehan Wu, Sudha Singh, Michael Byrne, Justin Wray, Suk-Hee Lee, Jac A Nickoloff and Robert Hromas

    Citation: Cell Division 2014 9:1

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  28. Content type: Review

    CSN6 is one subunit of the constitutive photomorphogenesis 9 (COP9) signalosome (CSN), which is an evolutionarily conserved multiprotein complex found in plants and animals and originally described as a repres...

    Authors: Shang-Nuan Zhang, Dong-Sheng Pei and Jun-Nian Zheng

    Citation: Cell Division 2013 8:14

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  29. Content type: Research

    We previously reported that a pool of low molecular weight peptides can be extracted by alkali treatment of DNA preparations obtained from prokaryotic and eukaryotic cells after intensive deproteinization. Thi...

    Authors: Loretta Mancinelli, Teresa Secca, Paula M De Angelis, Francesco Mancini, Matteo Marchesini, Cristiano Marinelli, Lanfranco Barberini and Francesco Grignani

    Citation: Cell Division 2013 8:11

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  30. Content type: Research

    The discovery of molecular markers associated with various breast cancer subtypes has greatly improved the treatment and outcome of breast cancer patients. Unfortunately, breast cancer cells acquire resistance...

    Authors: Katie R Hagen, Xiangbin Zeng, Mi-Young Lee, Shannon Tucker Kahn, Mary Kathryn Harrison Pitner, Sandra S Zaky, Yuan Liu, Ruth M O’Regan, Xingming Deng and Harold I Saavedra

    Citation: Cell Division 2013 8:10

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  31. Content type: Research

    The execution of meiotic nuclear divisions in S. cerevisiae is regulated by protein degradation mediated by the anaphase promoting complex/cyclosome (APC/C) ubiquitin ligase. The correct timing of APC/C activity ...

    Authors: Grace S Tan, Rebecca Lewandowski, Michael J Mallory, Randy Strich and Katrina F Cooper

    Citation: Cell Division 2013 8:9

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  32. Content type: Review

    The liver has a remarkable capacity to regenerate. Even with surgical removal (partial hepatectomy) of 70% of liver mass, the remnant tissue grows to recover the original mass and functions. Liver regeneration...

    Authors: Yuichiro Miyaoka and Atsushi Miyajima

    Citation: Cell Division 2013 8:8

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  33. Content type: Research

    Centrosomes function primarily as microtubule-organizing centres and play a crucial role during mitosis by organizing the bipolar spindle. In addition to this function, centrosomes act as reaction centers wher...

    Authors: Guillaume Chouinard, Isabelle Clément, Julie Lafontaine, Francis Rodier and Estelle Schmitt

    Citation: Cell Division 2013 8:7

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  34. Content type: Methodology

    The yeast Schizosaccharomyces pombe is frequently used as a model for studying the cell cycle. The cells are rod-shaped and divide by medial fission. The process of cell division, or cytokinesis, is controlled by...

    Authors: Daniel Schmitter, Paulina Wachowicz, Daniel Sage, Anastasia Chasapi, Ioannis Xenarios, Viesturs Simanis and Michael Unser

    Citation: Cell Division 2013 8:6

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  35. Content type: Research

    Cell division is positively regulated by cyclin-dependent kinases (CDKs) partnered with cyclins and negatively regulated by CDK inhibitors. In the frog, Xenopus laevis, three types of CDK inhibitors have been des...

    Authors: Xi-Ning Zhu, Dong Hyun Kim, Horng-Ru Lin, Varija N Budhavarapu, Herbert B Rosenbaum, Paul R Mueller and P Renee Yew

    Citation: Cell Division 2013 8:5

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