Protein arginine methylation: an emerging regulator of the cell cycle

Protein arginine methylation is a common post-translational modification where a methyl group is added onto arginine residues of a protein to alter detection by its binding partners or regulate its activity. I...

Authors: Anita E. Raposo and Sabine C. Piller

Subunits of human condensins are potential therapeutic targets for cancers

The main role of condensins is to regulate chromosome condensation and segregation during cell cycles. Recently, it has been suggested in the literatures that subunits of condensin I and condensin II are invol...

Authors: Hong-Zhen Wang, Si-Han Yang, Gui-Ying Li and Xudong Cao

Phasing in on the cell cycle

Just like all matter, proteins can also switch between gas, liquid and solid phases. Protein phase transition has claimed the spotlight in recent years as a novel way of how cells compartmentalize and regulate...

Authors: Steven Boeynaems, Peter Tompa and Ludo Van Den Bosch

The emerging roles of CDK12 in tumorigenesis

Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested ext...

Authors: Hana Paculová and Jiří Kohoutek

Proteins associated with the doubling time of the NCI-60 cancer cell lines

The varied nature of human cancers is recapitulated, at least to some extent, in the diverse NCI-60 panel of human cancer cell lines. Here, I used a basic, continuous variable of proliferating cells, their dou...

Authors: Michael Polymenis

Erratum to: Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae

Authors: Stephen K. Kim and Randy Strich

Erratum to: Electrostatic forces drive poleward chromosome motions at kinetochores

Authors: L. John Gagliardi and Daniel H. Shain

Multiple molecular interactions redundantly contribute to RB-mediated cell cycle control

The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle.

Authors: Michael J. Thwaites, Matthew J. Cecchini, Srikanth Talluri, Daniel T. Passos, Jasmyne Carnevale and Frederick A. Dick

Systematic epistatic mapping of cellular processes

Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure...

Authors: Maximilian Billmann and Michael Boutros

The Irr1/Scc3 protein implicated in chromosome segregation in Saccharomyces cerevisiae has a dual nuclear-cytoplasmic localization

Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it...

Authors: Piotr Kowalec, Jan Fronk and Anna Kurlandzka

Electrostatic forces drive poleward chromosome motions at kinetochores

Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet...

Authors: L. John Gagliardi and Daniel H. Shain

Erratum to: The loop-less ^tmCdc34 E2 mutant defective polyubiquitination in vitro and in vivo supports yeast growth in a manner dependent on Ubp14 and Cka2

Authors: Agnieszka Lass, Ross Cocklin, Kenneth M. Scaglione, Michael Skowyra, Sergey Korolev, Mark Goebl and Dorota Skowyra

The CSL proteins, versatile transcription factors and context dependent corepressors of the notch signaling pathway

The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve...

Authors: Humberto Contreras-Cornejo, Germán Saucedo-Correa, Javier Oviedo-Boyso, Juan José Valdez-Alarcón, Víctor Manuel Baizabal-Aguirre, Marcos Cajero-Juárez and Alejandro Bravo-Patiño

Interferon gamma-induced apoptosis of head and neck squamous cell carcinoma is connected to indoleamine-2,3-dioxygenase via mitochondrial and ER stress-associated pathways

Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and t...

Authors: Siraj M. El Jamal, Erin B. Taylor, Zakaria Y. Abd Elmageed, Abdulhadi A. Alamodi, Denis Selimovic, Abdulaziz Alkhateeb, Matthias Hannig, Sofie Y. Hassan, Simeon Santourlidis, Paul L. Friedlander, Youssef Haikel, Srinivasan Vijaykumar, Emad Kandil and Mohamed Hassan

Rpl22 is required for IME1 mRNA translation and meiotic induction in S. cerevisiae

The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt...

Authors: Stephen J. Kim and Randy Strich

Insights into APC/C: from cellular function to diseases and therapeutics

Anaphase-promoting complex/cyclosome (APC/C) is a multifunctional ubiquitin-protein ligase that targets different substrates for ubiquitylation and therefore regulates a variety of cellular processes such as c...

Authors: Zhuan Zhou, Mingjing He, Anil A. Shah and Yong Wan

Cullin-RING ligases in regulation of autophagy

Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process...

Authors: Danrui Cui, Xiufang Xiong and Yongchao Zhao

The structure and regulation of Cullin 2 based E3 ubiquitin ligases and their biological functions

Cullin-RING E3 ubiquitin ligase complexes play a central role in targeting cellular proteins for ubiquitination-dependent protein turnover through 26S proteasome. Cullin-2 is a member of the Cullin family, and...

Authors: Weijia Cai and Haifeng Yang

The T-box transcription factor TBX3 drives proliferation by direct repression of the p21^WAF1 cyclin-dependent kinase inhibitor

TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...

Authors: Tarryn Willmer, Shannagh Hare, Jade Peres and Sharon Prince

Cul3-KLHL20 ubiquitin ligase: physiological functions, stress responses, and disease implications

Cullin-RING ubiquitin ligases are the largest Ubiquitin ligase family in eukaryotes and are multi-protein complexes. In these complexes, the Cullin protein serves as a scaffold to connect two functional module...

Authors: Hsin-Yi Chen, Chin-Chih Liu and Ruey-Hwa Chen

New insights into posttranslational modifications of Hippo pathway in carcinogenesis and therapeutics

PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...

Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen and Yong Wan

Mitochondria-cytoskeleton associations in mammalian cytokinesis

The role of the cytoskeleton in regulating mitochondrial distribution in dividing mammalian cells is poorly understood. We previously demonstrated that mitochondria are transported to the cleavage furrow durin...

Authors: E. J. Lawrence, E. Boucher and C. A. Mandato

C1D family proteins in coordinating RNA processing, chromosome condensation and DNA damage response

Research on the involvement of C1D and its yeast homologues Rrp47 (S. cerevisiae) and Cti1 (S. pombe) in DNA damage repair and RNA processing has remained mutually exclusive, with most studies predominantly conce...

Authors: Rebecca A. Jackson, Jocelyn Shumei Wu and Ee Sin Chen

The role of cullin 5-containing ubiquitin ligases

The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...

Authors: Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa and Takumi Kamura

Curcumin and tumor immune-editing: resurrecting the immune system

Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...

Authors: Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee and Gaurisankar Sa