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Cell Division

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  1. Content type: Review

    Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and transcription. Since dysregulation of CDKs is a frequently occurring event driving tumorigenesis, CDKs have been tested ext...

    Authors: Hana Paculová and Jiří Kohoutek

    Citation: Cell Division 2017 12:7

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  2. Content type: Research

    The G1-S phase transition is critical to maintaining proliferative control and preventing carcinogenesis. The retinoblastoma tumor suppressor is a key regulator of this step in the cell cycle.

    Authors: Michael J. Thwaites, Matthew J. Cecchini, Srikanth Talluri, Daniel T. Passos, Jasmyne Carnevale and Frederick A. Dick

    Citation: Cell Division 2017 12:3

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  3. Content type: Commentary

    Genetic screens have identified many novel components of various biological processes, such as components required for cell cycle and cell division. While forward genetic screens typically generate unstructure...

    Authors: Maximilian Billmann and Michael Boutros

    Citation: Cell Division 2017 12:2

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  4. Content type: Research

    Correct chromosome segregation depends on the sister chromatid cohesion complex. The essential, evolutionarily conserved regulatory protein Irr1/Scc3, is responsible for the complex loading onto DNA and for it...

    Authors: Piotr Kowalec, Jan Fronk and Anna Kurlandzka

    Citation: Cell Division 2017 12:1

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  5. Content type: Commentary

    Recent experiments regarding Ndc80/Hec1 in force generation at kinetochores for chromosome motions have prompted speculation about possible models for interactions between positively charged molecules at kinet...

    Authors: L. John Gagliardi and Daniel H. Shain

    Citation: Cell Division 2016 11:14

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    The Erratum to this article has been published in Cell Division 2017 12:4

  6. Content type: Review

    The Notch signaling pathway is a reiteratively used cell to cell communication pathway that triggers pleiotropic effects. The correct regulation of the pathway permits the efficient regulation of genes involve...

    Authors: Humberto Contreras-Cornejo, Germán Saucedo-Correa, Javier Oviedo-Boyso, Juan José Valdez-Alarcón, Víctor Manuel Baizabal-Aguirre, Marcos Cajero-Juárez and Alejandro Bravo-Patiño

    Citation: Cell Division 2016 11:12

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  7. Content type: Research

    Tumor response to immunotherapy is the consequence of a concerted crosstalk between cytokines and effector cells. Interferon gamma (IFNγ) is one of the common cytokines coordinating tumor immune response and t...

    Authors: Siraj M. El Jamal, Erin B. Taylor, Zakaria Y. Abd Elmageed, Abdulhadi A. Alamodi, Denis Selimovic, Abdulaziz Alkhateeb, Matthias Hannig, Sofie Y. Hassan, Simeon Santourlidis, Paul L. Friedlander, Youssef Haikel, Srinivasan Vijaykumar, Emad Kandil and Mohamed Hassan

    Citation: Cell Division 2016 11:11

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  8. Content type: Research

    The transition from mitotic cell division to meiotic development in S. cerevisiae requires induction of a transient transcription program that is initiated by Ime1-dependent destruction of the repressor Ume6. Alt...

    Authors: Stephen J. Kim and Randy Strich

    Citation: Cell Division 2016 11:10

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    The Erratum to this article has been published in Cell Division 2017 12:5

  9. Content type: Review

    Cullin-RING ligases (CRLs), the largest E3 ubiquitin ligase family, promote ubiquitination and degradation of various cellular key regulators involved in a broad array of physiological and pathological process...

    Authors: Danrui Cui, Xiufang Xiong and Yongchao Zhao

    Citation: Cell Division 2016 11:8

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  10. Content type: Research

    TBX3, a member of the T-box family of transcription factors, is essential in development and has emerged as an important player in the oncogenic process. TBX3 is overexpressed in several cancers and has been s...

    Authors: Tarryn Willmer, Shannagh Hare, Jade Peres and Sharon Prince

    Citation: Cell Division 2016 11:6

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  11. Content type: Review

    PTMs (posttranslational modifications) such as ubiquitylation, sumoylation, acetylation and protein methylation are pivotal modifiers that determine the activation, deactivation or subcellular localization of ...

    Authors: Mingjing He, Zhuan Zhou, Anil A. Shah, Yang Hong, Qianming Chen and Yong Wan

    Citation: Cell Division 2016 11:4

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  12. Content type: Review

    The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase act...

    Authors: Fumihiko Okumura, Akiko Joo-Okumura, Kunio Nakatsukasa and Takumi Kamura

    Citation: Cell Division 2016 11:1

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  13. Content type: Review

    Curcumin has long been known to posses medicinal properties and recent scientific studies have shown its efficacy in treating cancer. Curcumin is now considered to be a promising anti-cancer agent and studies ...

    Authors: Sayantan Bose, Abir Kumar Panda, Shravanti Mukherjee and Gaurisankar Sa

    Citation: Cell Division 2015 10:6

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  14. Content type: Research

    Cullin-RING ubiquitin ligases (CRLs) are regulated by neddylation, which is a post translation modification of the Cullin family proteins. Neddylation of Cul1 activates the ligase through some means of biochem...

    Authors: Gil Bornstein and Chagai Grossman

    Citation: Cell Division 2015 10:5

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  15. Content type: Review

    The ubiquitin family member Sumo has important functions in many cellular processes including DNA repair, transcription and cell division. Numerous studies have shown that Sumo is essential for maintaining cel...

    Authors: Jorrit M. Enserink

    Citation: Cell Division 2015 10:4

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